Transient global amnesia after intake of tadalafil, a PDE-5 inhibitor: a possible association?
Int J Impot Res
; 17(4): 383-4, 2005.
Article
em En
| MEDLINE
| ID: mdl-15674402
ABSTRACT
Inhibitors of phosphodiesterase type 5 (PDE-5) are well established as an oral treatment for the majority of patients with erectile dysfunction (ED). PDE-5 is found in high concentration in smooth muscle cells of the corpora cavernosa. However, enzymes of the PDE family are also expressed in various other tissues, including the brain. Little is known about its effects on the central nervous system (CNS), although it has been suggested that PDE-5 inhibitors might cross the blood-brain barrier. Side effects, such as headache, nasal congestion, flushing, nausea, are much more common. We describe a patient who had a transient global amnesia (TGA) after his first-ever use of tadalafil, a potent PDE-5 inhibitor. Despite the fact that the aetiology of TGA has not entirely been clarified at present, we consider the hypothesis of a causal relationship as tempting with respect to the current hypotheses of TGA pathophysiology. This case, together with others, suggests that PDE-5 inhibitors might be capable of exerting adverse effects in the CNS. Physicians should be aware of the possibility of neurological disturbances when prescribing PDE-5 inhibitors for ED.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Fosfodiesterase
/
Carbolinas
/
3',5'-GMP Cíclico Fosfodiesterases
/
Amnésia Global Transitória
/
Disfunção Erétil
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Impot Res
Assunto da revista:
MEDICINA REPRODUTIVA
/
UROLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Alemanha