TNF-related apoptosis-inducing ligand (TRAIL) as a pro-apoptotic signal transducer with cancer therapeutic potential.
Curr Pharm Des
; 11(7): 933-44, 2005.
Article
em En
| MEDLINE
| ID: mdl-15777244
ABSTRACT
The powerful inducer of apoptosis Apo2L/TNF-related apoptosis-inducing ligand (TRAIL) has generated exciting promise as a potential tumour specific cancer therapeutic agent, since it selectively induces apoptosis in transformed versus normal cells. Interferons (IFNs) are important modulators of TRAIL expression, thus the ligand appears to play an important role in surveillance against viral infection and malignant transformation. In the light of the emerging importance of TRAIL in cancer therapy, we will discuss the molecular basis of the cooperation of TRAIL and IFNs or chemotherapeutic drugs. In particular, we will focus on the data known to date concerning the biochemical pathways leading to TRAIL-induced apoptosis in specific cancer cells and warranting further work to enable the investigation in cancer patients.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Transdução de Sinais
/
Fator de Necrose Tumoral alfa
/
Apoptose
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Pharm Des
Assunto da revista:
FARMACIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália