Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain.
Vaccine
; 23(24): 3196-201, 2005 May 02.
Article
em En
| MEDLINE
| ID: mdl-15837220
ABSTRACT
The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(OH)(3) adjuvant and CpG adjuvant). Titers of specific IgG antibodies in three test groups all peaked in the sixth week after first vaccination, but significant differences existed in the kinetics of specific IgG antibody levels. The strong neutralizing capacity exhibited in micro-cytopathic effect neutralization tests indicated the specific antibodies are protective. Western blot assay further demonstrated the specificity of the induced serum antibodies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Síndrome Respiratória Aguda Grave
/
Coronavírus Relacionado à Síndrome Respiratória Aguda Grave
/
Anticorpos Antivirais
Limite:
Animals
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China