Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer.
Cancer Lett
; 225(2): 245-51, 2005 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-15885892
ABSTRACT
Testicular cancer has been suggested to be primed in utero and there is familiar occurrence, particularly brothers and sons of men with testicular cancer have increased risk. Although no specific causative genotoxic agents have been identified, variations in DNA repair capacity could be associated with the risk of testicular cancer. A case-control study of 184 testicular cancer cases and 194 population-based controls living in the Copenhagen Greater Area in Denmark was performed. We found that neither polymorphisms in several DNA repair genes nor alleles of several polymorphisms in the chromosomal of region 19q13.2-3, encompassing the genes ASE, ERCC1, RAI and XPD, were associated with risk of testicular cancer in Danish patients. This is in contrast to other cancers, where we reported strong associations between polymorphisms in ERCC1, ASE and RAI and occurrence of basal cell carcinoma, breast cancer and lung. To our knowledge this is the first study of DNA repair gene polymorphisms and risk of testicular cancer.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Testiculares
/
Polimorfismo de Nucleotídeo Único
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Reparo do DNA
/
Nucleotídeos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Dinamarca