Your browser doesn't support javascript.
loading
Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone.
Koyama, Rikako; Nakanishi, Koji; Kato, Masako; Yamashita, Shigeo; Kuwahara, Hiroya; Katori, Hideyuki.
Afiliação
  • Koyama R; Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Am J Med Sci ; 329(5): 259-64, 2005 May.
Article em En | MEDLINE | ID: mdl-15894868
Two diabetic patients, who had been treated with human insulin, suffered from fasting hypoglycemia and postprandial hyperglycemia. The insulin-binding capacities of their sera were high, and a large amount of total insulin and prolonged presence of free insulin in the sera were shown. Scatchard analysis of these insulin antibodies revealed that high-affinity insulin antibodies had larger capacity and stronger affinity compared with commonly insulin-treated patients. Treatment with double filtration plasmapheresis and subsequent administration of prednisolone in the second patient reduced such antibodies and resulted in recovery of glycemic control by insulin. Hypoglycemia and hyperglycemia could be incurred when insulin antibodies with strong affinity and high capacity in high-affinity sites arise. This condition can be treated with double filtration plasmapheresis and subsequent administration of prednisolone.
Assuntos
Buscar no Google
Base de dados: MEDLINE Assunto principal: Prednisolona / Diabetes Mellitus / Hiperglicemia / Hipoglicemia / Anticorpos Anti-Insulina Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Med Sci Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Japão
Buscar no Google
Base de dados: MEDLINE Assunto principal: Prednisolona / Diabetes Mellitus / Hiperglicemia / Hipoglicemia / Anticorpos Anti-Insulina Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Med Sci Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Japão