Paradigm shift in NMDA receptor drug development.
Expert Opin Ther Targets
; 9(3): 427-9, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15948664
ABSTRACT
Low-affinity, uncompetitive antagonists with rapid 'off-rates', such as memantine offer protection from dementia and other neurological disorders, but break all the old rules of screening for new drugs by high-affinity binding.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de N-Metil-D-Aspartato
/
Fármacos Neuroprotetores
Limite:
Humans
Idioma:
En
Revista:
Expert Opin Ther Targets
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2005
Tipo de documento:
Article