Assessing combination treatments in acute stroke: preclinical experiences.
Behav Brain Res
; 162(2): 165-72, 2005 Jul 30.
Article
em En
| MEDLINE
| ID: mdl-15970214
ABSTRACT
BACKGROUND:
Acute ischemic stroke is a complex disease. Treatment success may require combining different therapeutic approaches. An obvious treatment combination in acute ischemic stroke is a thrombolytic therapy, adjuvant with a neuroprotective agent to have better stroke recovery. SUMMARY OF REVIEW Complete factorial designs can assess the synergy of combination treatments and distinguish them from supper-additive, additive or sub-additive effects. A factorial design, a two-way analysis of variance and a novel graphic technique can detect and illustrate interactions of two treatments, which were used to evaluate combination treatments to extend the therapeutic window for thrombolytic therapy in an embolic stroke model on rats. We hypothesized synergy or additive effects on stroke recovery when combining thrombolytic therapy with either an antagonist to the integrin CD11b/CD18 (UK-279,276) or a glycoprotein IIb/IIIa receptor inhibitor.CONCLUSIONS:
Factorial designs offer an efficient approach to study synergistic effects of two treatments. Our graphical technique provides a powerful, intuitive and quantitative explanation of joint treatment effects. Combining thrombolytic therapy with a neuroprotectant yielded a super-additive or additive treatment effect for two preclinical experiments designed to extend the thrombolytic therapeutic window for stroke.
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Base de dados:
MEDLINE
Assunto principal:
Terapia Trombolítica
/
Fármacos Neuroprotetores
/
Acidente Vascular Cerebral
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos