PromoterPlot: a graphical display of promoter similarities by pattern recognition.
Nucleic Acids Res
; 33(Web Server issue): W423-6, 2005 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-15980503
ABSTRACT
PromoterPlot (http//promoterplot.fmi.ch) is a web-based tool for simplifying the display and processing of transcription factor searches using either the commercial or free TransFac distributions. The input sequence is a TransFac search (public version) or FASTA/Affymetrix IDs (local install). It uses an intuitive pattern recognition algorithm for finding similarities between groups of promoters by dividing transcription factor predictions into conserved triplet models. To minimize the number of false-positive models, it can optionally exclude factors that are known to be unexpressed or inactive in the cells being studied based on microarray or proteomic expression data. The program will also estimate the likelihood of finding a pattern by chance based on the frequency observed in a control set of mammalian promoters we obtained from Genomatix. The results are stored as an interactive SVG web page on our server.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Gráficos por Computador
/
Software
/
Regulação da Expressão Gênica
/
Regiões Promotoras Genéticas
/
Genômica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nucleic Acids Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Suíça