[Changes of brain p38 MAPK in rabbits with craniocerebral gunshot injury in hot and humid environment].
Di Yi Jun Yi Da Xue Xue Bao
; 25(9): 1155-7, 2005 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-16174586
ABSTRACT
OBJECTIVE:
To study the activation of p38 mitogen-activated protein kinase (MAPK) in the brain of rabbits after craniocerebral gunshot injury in a hot and humid environment (HHE) and explore its possible mechanism.METHODS:
Craniocerebral gunshot injury model was established in 30 New Zealand white rabbits, which were subsequently exposed to environment of normal temperature (at 22.0% +/- 0.5 degrees C; with relative humidity of 50%) or HHE at 39.0 +/- 0.5 degrees C; with relative humidity of 80%-85% for 10 min, 30 min, 1 h, 1.5 h, and 2 h groups, respectively, with 5 rabbits in each group. p38 MAPK activity in the brain tissues of the rabbits following the injury and environmental exposure were detected by Western blotting and analyzed semi-quantitatively by Bio-Profil gel image analysis system.RESULTS:
p38 MAPK activity in the cortex and hypothalamus was significantly elevated following gunshot injury and HHE exposure, reaching the peak level at 1 h of HHE exposure and then decreased. p38 MAPK activity was significantly higher in the hypothalamus than in the cortex.CONCLUSION:
p38 MAPK activity increases in the early stage following craniocerebral gunshot injury and HHE exposure in rabbits, the mechanism of which might involve the secondary brain insult.
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Base de dados:
MEDLINE
Assunto principal:
Ferimentos por Arma de Fogo
/
Proteínas Quinases p38 Ativadas por Mitógeno
/
Traumatismos Craniocerebrais
/
Temperatura Alta
Limite:
Animals
Idioma:
Zh
Revista:
Di Yi Jun Yi Da Xue Xue Bao
Assunto da revista:
MEDICINA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China