Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin.
Korean J Parasitol
; 43(3): 123-6, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16192755
ABSTRACT
Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Artemisininas
/
Antimaláricos
Limite:
Animals
Idioma:
En
Revista:
Korean J Parasitol
Ano de publicação:
2005
Tipo de documento:
Article