The HNPCC associated MSH2*1906G-->C founder mutation probably originated between 1440 CE and 1715 CE in the Ashkenazi Jewish population.
J Med Genet
; 42(10): 766-8, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16199548
ABSTRACT
The MSH2*1906G-->C mutation was recently shown to be a rare yet highly penetrant mutation leading to colorectal cancer. The mutation was only found among Ashkenazi Jewish individuals and lies on an extended haplotype that is common in that population. This study determined that the mutation probably arose between 11 and 22 generations ago, during the time when the Ashkenazim were living in eastern Europe.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Neoplasias Colorretais Hereditárias sem Polipose
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Efeito Fundador
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Predisposição Genética para Doença
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Proteína 2 Homóloga a MutS
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Mutação
Tipo de estudo:
Health_economic_evaluation
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Med Genet
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Canadá