A simple tool to explore the distance distribution of correlated mutations in proteins.
Biophys Chem
; 119(3): 240-6, 2006 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-16239060
ABSTRACT
The analysis of correlated mutations in protein sequence alignments is of considerable interest, since it may provide useful energetic and even structural information (ideally, residue contacts). However, a number of recent experimental studies support the existence of long-distance communication in proteins, a fact that may lead to correlation between distant residues. We introduce in this work a simple statistical procedure to describe the relation structure--alignments on the basis of the residue--residue distance dependence of the number of residue couples over given thresholds of a correlation measure (such as a covariance value). This procedure may lead to clear pictures of the distance distribution of correlated mutations and may provide a simple but efficient tool to explore the different structural features that are reflected in the sequence alignments.
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Base de dados:
MEDLINE
Assunto principal:
Tiorredoxinas
/
Proteínas
/
Alinhamento de Sequência
/
Aminoácidos
/
Mutação
Idioma:
En
Revista:
Biophys Chem
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha