An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.
Nat Genet
; 37(12): 1320-2, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16258542
ABSTRACT
A substantial investment has been made in the generation of large public resources designed to enable the identification of tag SNP sets, but data establishing the adequacy of the sample sizes used are limited. Using large-scale empirical and simulated data sets, we found that the sample sizes used in the HapMap project are sufficient to capture common variation, but that performance declines substantially for variants with minor allele frequencies of <5%.
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Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Mapeamento Cromossômico
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Bases de Dados de Ácidos Nucleicos
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Evaluation_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Genet
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido