Rapid detection of pneumococcal antigen in serum samples for diagnosing pneumococcal pneumonia.
J Infect
; 53(1): 21-4, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16269180
ABSTRACT
OBJECTIVES:
The aim of the study is to assess the usefulness of C polysaccharide and polysaccharide capsular antigen detection by immunochromatography (ICT) and enzyme immunoassay (EIA), respectively, in serum samples for diagnosing pneumococcal pneumonia.METHODS:
Adult patients included in the study were classified in the following groups In group 1 we studied 101 serum samples from patients with pneumonia due to Streptococcus pneumoniae. In 53 cases the pneumonia was bacteremic. The second group contained 113 serum samples from patients with no pneumococcal pneumonia. Group 3 was made up of 40 serum samples from healthy subjects with no clinical or radiological signs of pneumonia.RESULTS:
Using ICT, antigen was detected in 50% of patients with pneumococcal pneumonia, in 64.3 and 40.9% of patients with bacteremic and non-bacteremic pneumococcal pneumonia, respectively. Using EIA, antigens were detected in 35.8% of patients with pneumococcal pneumonia, in 45 and 22.2% of patients with bacteremic and non-bacteremic pneumococcal pneumonia, respectively.CONCLUSIONS:
In conclusion, the sensitivity of the tests is low. However, in special situations, where obtaining large volume of urine is difficult, they could be a complementary method in the rapid diagnosis of pneumococcal pneumonia.
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia Pneumocócica
/
Polissacarídeos Bacterianos
/
Streptococcus pneumoniae
/
Cápsulas Bacterianas
/
Antígenos de Bactérias
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
J Infect
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha