[Additive effect of intravenous prednisolone for acute severe asthma in infants and toddlers: a randomized controlled clinical trial].
Arerugi
; 54(10): 1190-6, 2005 Oct.
Article
em Ja
| MEDLINE
| ID: mdl-16407665
ABSTRACT
BACKGROUND:
The efficacy of systemic corticosteroids for infants and toddlers with acute severe asthma has been inadequately evaluated.OBJECTIVE:
The purpose of this study was to evaluate the additive efficacy of intravenous prednisolone in a randomized controlled study in the management of infants and toddlers with acute severe asthma.METHODS:
Sixty-two patients (aged 8 to 70 months) hospitalized with status asthmaticus were studied. They were randomized into two groups. One group received intravenous prednisolone treatment (1 approximately 3 mg/kg/day, 3 days); the other group served as a control. Each group received continuous aminophylline infusion and low-dose continuous isoproterenol inhalation by an Inspiron nebulizer. They were monitored their heart rate, respiratory rate and symptoms (Wood's clinical score).RESULTS:
Each group showed rapid improvement in heart rate, respiratory rate and clinical score by low-dose continuous isoproterenol inhalation. There were no significant differences in the time course of these clinical indexes or the duration of aminophylline infusion, continuous isoproterenol inhalation and hospital stay.CONCLUSION:
This study failed to confirm the additive benefit of intravenous prednisolone in the management of infants and toddlers with acute severe asthma.
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Base de dados:
MEDLINE
Assunto principal:
Estado Asmático
/
Prednisolona
Tipo de estudo:
Clinical_trials
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Ja
Revista:
Arerugi
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Japão