Heme and innate immunity: new insights for an old molecule.
Mem Inst Oswaldo Cruz
; 100(7): 799-803, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16410972
ABSTRACT
Hemolytic episodes such as sickle cell disease, malaria and ischemia-reperfusion occurrence are often associated to the statement of an inflammatory response which may develop or not to a chronic inflammatory status. Although these pathological states are triggered by distinct etiological agents, all of them are associated to high levels of free heme in circulation. In this review, we aim to focus the very recent achievements that have led to the statement of free heme as a proinflammatory molecule, which may play a central role during the onset and/or persistence of inflammation during these pathologies.
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Base de dados:
MEDLINE
Assunto principal:
Heme
/
Hemólise
/
Imunidade Inata
/
Inflamação
Limite:
Humans
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Brasil