Pilot study to determine the efficacy of ALA-PDT photo-rejuvenation for the treatment of facial ageing.
J Cosmet Laser Ther
; 7(3-4): 159-62, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16414903
ABSTRACT
OBJECTIVE:
The study was divided into two parts. The objective of the preliminary study was to evaluate the optimum dose and tolerance of 5-aminolaevulinic acid (5-ALA) compared to a placebo cream with a 633-nm LED light in normal, healthy, volunteer forearm skin. The second study was to establish if ALA-PDT treatments improve the signs of ageing.RESULTS:
Threshold photosensitization was observed using 5% 5-ALA under plastic occlusion for 30 minutes following a dose response study of forearm skin. Mild improvement was observed, using this concentration and time, for periorbital skin aging. Other anecdotal positive results of photo-rejuvenation are reported for facial and chest areas.
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Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Envelhecimento da Pele
/
Fármacos Fotossensibilizantes
/
Ácido Aminolevulínico
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
J Cosmet Laser Ther
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido