Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential.
Semin Immunol
; 18(2): 103-10, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16458533
ABSTRACT
CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) are critical for the regulation of tolerance and have shown enormous potential in suppressing pathological immune responses in autoimmune disease, transplantation, and graft-versus-host disease (GVHD). Recent data indicate that suppression of organ-specific autoimmunity is critically dependent on the antigen specificity of the Treg. An emerging model of Treg action is that organ-specific Treg acquire suppressive activity through activation by dendritic cells expressing organ-derived antigens. Thus, efficacy of Treg-based therapy should be increased by using organ-specific Treg rather than polyclonal Treg. This necessitates the ability to identify relevant antigens and to expand rare antigen-specific Treg from diverse polyclonal populations. Here, we consider the importance of antigen specificity in Treg function and discuss recent advances for the expansion of antigen-specific Treg and the therapeutic potential of Treg in controlling autoimmunity and GVHD.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Imunoterapia Adotiva
/
Linfócitos T Reguladores
/
Epitopos de Linfócito T
/
Proliferação de Células
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos