Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures.
J Neuroimmunol
; 33(1): 73-9, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1647411
ABSTRACT
We report a patient with a progressive, predominantly sensory neuropathy and a IgM kappa M-protein that binds to Schmidt-Lantermann incisures. A sural nerve biopsy showed primary axonal damage and IgM deposits at Schmidt-Lantermann incisures were seen by direct immunoperoxidase. Serum from the patient injected into rat sciatic nerve reacts with the incisures as with those in the patient's nerve. The IgM kappa M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa. Peripheral neuropathy may be related to the M-protein, which had immunocytochemical reactivity not previously described for patients with polyneuropathy and IgM monoclonal gammopathy.
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Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Imunoglobulina M
/
Imunoglobulinas
/
Proteínas Sanguíneas
/
Cadeias kappa de Imunoglobulina
/
Doenças do Sistema Nervoso Periférico
/
Fibras Nervosas Mielinizadas
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Itália