GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution.
Nat Cell Biol
; 8(3): 238-48, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16489344
ABSTRACT
The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose of, Golgi ribbon formation are known. Here, we demonstrate that ribbon formation is mediated by specific membrane-fusion events that occur during Golgi assembly, and require the Golgi proteins GM130 and GRASP65. Furthermore, these GM130 and GRASP65-dependent lateral cisternal-fusion reactions are necessary to achieve uniform distribution of enzymes in the Golgi ribbon. The membrane continuity created by ribbon formation facilitates optimal processing conditions in the biosynthetic pathway.
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Base de dados:
MEDLINE
Assunto principal:
Complexo de Golgi
/
Membranas Intracelulares
/
Fusão de Membrana
/
Proteínas de Membrana
Limite:
Humans
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos