Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies.
Nat Genet
; 38(5): 556-60, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16582909
ABSTRACT
The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.
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Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Desequilíbrio de Ligação
/
Genética Populacional
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Genet
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos