Linking lipids, Alzheimer's and LXRs?
Nucl Recept Signal
; 2: e001, 2004.
Article
em En
| MEDLINE
| ID: mdl-16604185
ABSTRACT
Deposition of the beta-amyloid (Abeta) peptide is thought to underlie development of Alzheimer's disease (AD). This pathological linkage has spurred considerable interest in therapeutic strategies to reduce Abeta production. It is becoming increasingly clear that altered cholesterol homeostasis can modulate Abeta production and/or accumulation. In this review, we discuss the molecular pathology of AD, the cholesterol connection and recent data suggesting that the oxysterol receptor, liver X receptor LXR (NR1H2 and NR1H3), may modulate these events.
Texto completo:
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Nucl Recept Signal
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos