The Steap proteins are metalloreductases.
Blood
; 108(4): 1388-94, 2006 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-16609065
ABSTRACT
Iron and copper are essential for all organisms, assuming critical roles as cofactors in many enzymes. In eukaryotes, the transmembrane transport of these elements is a highly regulated process facilitated by the single electron reduction of each metal. Previously, we identified a mammalian ferrireductase, Steap3, critical for erythroid iron homeostasis. Now, through homology, expression, and functional studies, we characterize all 4 members of this protein family and demonstrate that 3 of them, Steap2, Steap3, and Steap4, are not only ferrireductases but also cupric reductases that stimulate cellular uptake of both iron and copper in vitro. Finally, the pattern of tissue expression and subcellular localization of these proteins suggest they are physiologically relevant cupric reductases and ferrireductases in vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
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Regulação Enzimológica da Expressão Gênica
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Coenzimas
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Cobre
/
Ferro
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Antígenos de Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos