EGFR as a target: rationale for therapy.
Semin Oncol Nurs
; 22(1 Suppl 1): 5-9, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16616281
ABSTRACT
OBJECTIVES:
To review the biology of the EGFR, its structure, and the associated signal transduction pathways. To provide an overview of the role of EGFR in normal physiology and the pathophysiology of malignancy. Current anti-EGFR treatments are also discussed. DATA SOURCES Research articles.CONCLUSION:
EGFR is a valid target in the treatment of solid tumors. EGFR abnormalities and dysfunction are involved in various aspects of carcinogenesis and tumor progression, and EGFR is overexpressed in several tumor types. The development of anti-EGFR therapies represents an important advance in cancer therapy. IMPLICATIONS FOR NURSING PRACTICE Anti-EGFR therapy is currently available in the clinical setting. Nurses involved in the care of patients with cancer can benefit from an increased understanding of the normal and abnormal function of EGFR in the body and the mechanisms by which anti-EGFR therapies act.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteínas Quinases
/
Receptores ErbB
/
Anticorpos Monoclonais
/
Neoplasias
/
Antineoplásicos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Semin Oncol Nurs
Assunto da revista:
ENFERMAGEM
/
NEOPLASIAS
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos