Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia.
Leuk Res
; 31(1): 105-8, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-16725199
ABSTRACT
Arsenic trioxide (As(2)O(3)) is highly efficacious for acute promyelocytic leukemia (APL). Environmental arsenic exposure predisposes to malignancies, but the risk for therapeutic arsenic is undefined. Three APL patients (de novo, 2; therapy-related, 1) in a cohort of 59 cases given oral-As(2)O(3) for induction and maintenance treatment developed secondary cancers (nasopharyngeal carcinoma, 2; colonic adenocarcinoma, 1) at 16, 36 and 55 months post-As(2)O(3) therapy. Retrospective analysis of biomarkers (Epstein Barr virus serology and quantification, carcinoembryonic antigen) showed the potential presence of cancers before or shortly after As(2)O(3) therapy, suggesting that As(2)O(3) had not initiated these malignancies. Compared against matched background population, there was an increased risk of second cancer (p=0.012, standard incidence ratio=6.5; 95% confidence interval=1.4-19.0).
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Base de dados:
MEDLINE
Assunto principal:
Óxidos
/
Arsenicais
/
Leucemia Promielocítica Aguda
/
Adenocarcinoma
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Neoplasias Nasofaríngeas
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Neoplasias do Colo
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Neoplasias
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Hong Kong