Prenatal covering of the spinal cord decreases neurologic sequelae in a myelomeningocele model.
J Pediatr Surg
; 41(6): 1125-9, 2006 Jun.
Article
em En
| MEDLINE
| ID: mdl-16769346
ABSTRACT
BACKGROUND/PURPOSE:
Recent experience in fetal surgery to correct myelomeningocele in humans reports an early reversion of hydrocephalus and decreased need of ventricular shunting in the first months of life; however, it has not been possible to demonstrate benefit in lower extremity function. In the present work, we have tried to ascertain the impact of cord exposure on hind limb function.METHODS:
Fetal rabbits with myelomeningocele (group M), treated myelomeningocele (group T), and control animals (group C) were compared at birth regarding physical examination, somatosensory-evoked potentials of the hind limbs, ventricular morphometry, and spine histology.RESULTS:
No major difference was found between groups M and T in the physical examination. Somatosensory-evoked potentials of the hind limbs were absent in group M and present in group T, although showing a longer latency period and decreased amplitude than controls. The area of the third ventricle was significantly larger in group M than in group C; in group T, it was also somewhat larger but not significantly so. Cord histology had evident changes in group M and minor changes in group T, which resembled normal group C cord.CONCLUSIONS:
Prenatal covering of the spinal cord prevents central and peripheral neurologic deterioration in this animal model of myelomeningocele.
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Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Retalhos Cirúrgicos
/
Meningomielocele
/
Doenças Fetais
/
Doenças do Sistema Nervoso
Limite:
Animals
Idioma:
En
Revista:
J Pediatr Surg
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha