Synthesis of substituted benzoxacycles via a domino ortho-alkylation/Heck coupling sequence.
J Org Chem
; 71(13): 4937-42, 2006 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-16776524
ABSTRACT
The synthesis of a variety of alkylidene benzoxacycles via a domino palladium-catalyzed ortho-alkylation/intramolecular Heck reaction is described. Under the optimized conditions [Pd(OAc)2 (10 mol %), P(2-Furyl)3 (20 mol %), norbornene (4 equiv), Cs2CO3 (2 equiv), CH3CN, 80 degrees C], aryl iodides with oxygen-tethered Heck acceptors are coupled with alkyl bromides (5 equiv) to generate a variety of six- and seven-membered-ring benzoxacyclic products.
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Base de dados:
MEDLINE
Assunto principal:
Benzoxazinas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2006
Tipo de documento:
Article