Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.
Cancer Lett
; 247(2): 328-35, 2007 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-16815628
ABSTRACT
Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C including G(3436)-A(3944)-C(20965)-C(30056), (G or C)-A-C-C and G-A-(C or T)-C were significantly associated with increased risk (odds ratios between 1.95 and 2.37). These findings suggest various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Raios Ultravioleta
/
Haplótipos
/
Receptores de Calcitriol
/
Polimorfismo de Nucleotídeo Único
Limite:
Humans
/
Male
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido