High-resolution X-ray microtomography is a sensitive method to detect vascular calcification in living rats with chronic renal failure.
Arterioscler Thromb Vasc Biol
; 26(9): 2110-6, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16840714
ABSTRACT
OBJECTIVE:
Chronic renal failure (CRF) is associated with a 10- to 20-fold increase in cardiovascular risk. Vascular calcification is a prominent feature of cardiovascular disease in patients with end-stage renal failure and contributes to the excess mortality in this population. In this study, we explored in vivo X-ray microtomography (micro-CT) as a tool to detect and follow-up vascular calcifications in the aorta of living rats with adenine-induced CRF. METHODS ANDRESULTS:
With in vivo micro-CT, calcification of the aorta in uremic rats was clearly discernible on transversal virtual cross-sections. Micro-CT findings correlated well with tissue calcium content and histology. Repetitive scans in animals with light, moderate, and severe vascular calcification showed good reproducibility with minimal interference of motion artifacts. Moreover, both calcified volume and area could be quantified with this method.CONCLUSIONS:
In vivo micro-CT scanning is a sensitive method to detect vascular calcifications in CRF rats, allowing follow-up and quantification of the development, and potential reversal during treatment, of vascular calcifications in living animals.
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Base de dados:
MEDLINE
Assunto principal:
Doenças da Aorta
/
Calcinose
/
Tomografia Computadorizada por Raios X
/
Falência Renal Crônica
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Arterioscler Thromb Vasc Biol
Assunto da revista:
ANGIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Bélgica