[Therapeutic effect of whole body hyperthermia combined with chemotherapy in patients with advanced cancer].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 31(3): 350-2, 2006 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-16859121
ABSTRACT
OBJECTIVE:
To determine the short-term efficacy and security of whole body hyperthermia (WBH) combined with chemotherapy for advanced cancer.METHODS:
Different chemotherapy regimens were applied in 138 patients with advanced cancer. Among them, 68 patients (Group A) didn't receive any other therapies. The other 70 patients (Group B) received WBH together with chemotherapy. WBH was maintained at 40 degrees C approximately 42 degrees C for 50 approximately 60 min (once or twice every week and 4 times a cycle).RESULTS:
In Group A, the rate of complete remission (CR) was 2.9%, partial remission (PR) was 36.8%, stable disease was 35.3%, progressive disease was 25.0%, the overall response rate (CR + PR) was 39.7%; while in Group B, the corresponding figures were 5.7%, 52.9%, 25.7%, 25.0%, and 58.6%, respectively. There was significant difference between the two groups (P < 0.05). The rates of III + IV gastrointestinal tract andmyelosuppression toxicities were 26.5% and 16.2% in Group A, while 27.1% and 18.6% in Group B. No significant difference was found.CONCLUSION:
WBH combined with chemotherapy is efficient and safe for advanced cancer, and is worth generalizing extensively.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Hipertermia Induzida
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Neoplasias Pulmonares
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
Zh
Revista:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Assunto da revista:
MEDICINA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
China