Preparation of poly epsilon-caprolactone nanoparticles containing magnetite for magnetic drug carrier.
Int J Pharm
; 324(2): 185-90, 2006 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-16872766
ABSTRACT
Magnetic poly epsilon-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
/
Portadores de Fármacos
/
Nanopartículas
/
Magnetismo
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Coréia do Sul