Structure-activity relationships in platelet-activating factor. Part 13: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity.
Bioorg Med Chem
; 14(23): 8109-25, 2006 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-16893650
ABSTRACT
HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Fator de Ativação de Plaquetas
/
Síndrome da Imunodeficiência Adquirida
/
Fármacos Anti-HIV
/
Demência
/
Antirretrovirais
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
França