The role of the transcription factor Foxp3 in the development of regulatory T cells.
Immunol Rev
; 212: 86-98, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16903908
ABSTRACT
Early studies of mice subjected to neonatal thymectomy and analyses of adoptive T-cell transfer into lymphopenic hosts led to the identification of a specialized subset of regulatory CD4+ T cells capable of suppressing various manifestations of autoimmunity. Recently, a combination of genetic, molecular, and traditional cellular approaches provided novel powerful means to investigate the biology of these cells. Here, we review earlier and current work from our laboratory, establishing a dedicated function for the transcription factor Foxp3 in the process of regulatory T-cell lineage commitment and a role for TCR- and cytokine-mediated signals in regulation of Foxp3 expression.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Reguladores
/
Fatores de Transcrição Forkhead
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Immunol Rev
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos