ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia.
Haematologica
; 91(9): 1277-8, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16956834
ABSTRACT
The association of endothelin 1 (ET-1) and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphisms (G5665T and T8002C, VNTR and T-786C respectively) with the occurrence of acute chest syndrome and painful vaso-occlusive crises was evaluated in homozygous SS children. This retrospective study reveals that ET-1 T8002 and ecNOS C-786 alleles are associated with, respectively, an increased and a decreased risk of acute chest syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Endotelina-1
/
Óxido Nítrico Sintase Tipo III
/
Anemia Falciforme
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Haematologica
Ano de publicação:
2006
Tipo de documento:
Article