Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients.
Nephrol Dial Transplant
; 21(12): 3555-8, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-16968732
ABSTRACT
BACKGROUND:
Thrombophilia has been implicated in the development of avascular necrosis (AVN) in various diseases. We aimed to search for the relation of both prothrombin gene G20210A mutation and factor V G1691A (factor V Leiden) mutation with AVN among kidney transplant recipients.METHODS:
Nineteen patients with AVN and 38 control patients without AVN were included. Clinical information was collected, and gender, age, type of renal allograft, duration and type of dialysis, presence of acute rejection, and cumulative doses of ciclosporin and corticosteroid administration were taken into consideration. Genotypes of factor V G1691A and prothrombin G20210A were determined by direct sequencing of genomic DNA.RESULTS:
Factor V Leiden mutation was detected in six patients (31.6%) among patients with AVN and in only three patients (7.9%) in the control group (P = 0.048). Two patients (10.5%) in the AVN group were determined to have prothrombin G20210A mutation, while no prothrombin G20210A mutation was detected in the control group. When both of the mutations causing thrombophilia were considered, a total of eight patients (42.1%) in the AVN group and three patients (7.9%) in the control group were identified (P = 0.004).CONCLUSION:
Thrombophilia seems to be an important risk factor for development of AVN. More studies are needed to clarify the role of factor V G1691A and prothrombin G20210A mutation for AVN.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Fator V
/
Protrombina
/
Transplante de Rim
/
Trombofilia
/
Necrose da Cabeça do Fêmur
/
Mutação
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nephrol Dial Transplant
Assunto da revista:
NEFROLOGIA
/
TRANSPLANTE
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Turquia