Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome.
Intensive Care Med
; 32(11): 1881-8, 2006 Nov.
Article
em En
| MEDLINE
| ID: mdl-16977483
ABSTRACT
OBJECTIVE:
To evaluate the effects of hyperbaric oxygen (HBO) therapy on the coagulation cascade using an experimental model of multiple organ failure syndrome (MOFS).DESIGN:
MOFS was induced by zymosan (500mg/kg i.p.) in rats. HBO therapy (2ATA) was administered in a cylindrical steel chamber 4 and 11h after zymosan administration. In a separate set of experiments animals were monitored for 72h, and systemic toxicity was scored. INTERVENTION Eighteen hours after zymosan administration, rats were killed and blood samples were used for analysis of hemocoagulative parameters, hemodynamics, and arterial blood gas. MAINRESULTS:
Zymosan administration caused MOFS by affecting the coagulation cascade, as shown by a significant increase in plasma levels of fibrinogen, tissue plasminogen activator, inhibitor of tissue plasminogen activator of type 1, and plasma levels of fibrin degradation products vs. control rats. Zymosan-induced MOFS was also characterized by a significant increase in von Willebrand antigen plasma levels vs. controls. Moreover, zymosan administration induced a significant fall in mean arterial blood pressure and alteration in blood gas values. HBO therapy significantly reduced the derangements of coagulation cascade, the fall in mean blood pressure and alteration in blood gas induced by zymosan administration.CONCLUSIONS:
The hypercoagulability induced by zymosan could be responsible for organ failure and death. Our data demonstrate that HBO therapy significantly prevents the alteration in the coagulation cascade and arterial blood gas in an experimental model of MOFS.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Oxigenoterapia Hiperbárica
/
Insuficiência de Múltiplos Órgãos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Intensive Care Med
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália