Tandem Wittig rearrangement/aldol reactions for the synthesis of glycolate aldols.
Org Lett
; 8(20): 4661-3, 2006 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-16986975
ABSTRACT
A new tandem Wittig Rearrangement/aldol reaction of O-benzyl or O-allyl glycolate esters is described. This reaction generates two carbon-carbon bonds and two contiguous stereocenters in a single step from simple starting materials. The [1,2]-Wittig rearrangement proceeds under very mild reaction conditions that do not require the use of a strong base, and the 1,2-diol products are obtained in good yield with excellent diastereoselectivity (>201).
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Base de dados:
MEDLINE
Assunto principal:
Aldeídos
/
Glicolatos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos