[Misleadingly high amylase and pancreatic amylase activity in the plasma of patients with macroamylasemia]. / Misleidende hoge amylase- en pancreasamylase-activiteit in het serum van een patiënt met macro-amylasemie.
Ned Tijdschr Geneeskd
; 134(35): 1705-7, 1990 Sep 01.
Article
em Nl
| MEDLINE
| ID: mdl-1699137
ABSTRACT
A man aged 68 years with choledocholithiasis and cholangitis, with no clinical signs suggestive of acute pancreatitis and with a low excretion of amylase in the urine, showed persistent hyperamylasaemia which appeared to be caused by macroamylasaemia. The macroamylase (an IgA-lambda-amylase complex) accounted for nearly all (90%) of the amylase activity in the serum. The activity of pancreatic amylase in serum, determined by an immunoinhibition test which selectively blocks salivary amylase activity, constituted 99% of the amylase activity in serum (normal reference range 19-71). We showed, however, that complexed salivary amylase is not inhibited in the test, resulting in a falsely-increased activity of pancreatic amylase in serum. We conclude that macroamylasaemia can lead to a clinically misleading increase in the activity of pancreatic amylase in serum.
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Base de dados:
MEDLINE
Assunto principal:
Amilases
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Ano de publicação:
1990
Tipo de documento:
Article