Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland.
Med Hypotheses
; 68(2): 314-7, 2007.
Article
em En
| MEDLINE
| ID: mdl-16997495
ABSTRACT
Myoepithelioma is a rare benign neoplasm of the salivary glands occurring more frequently in the parotids. Myasthenia gravis (MG) is a chronic, T-cell dependent, antibody and complement-mediated autoimmune neuromuscular transmission disorder. Interleukine-6 (IL-6) is an immune protein belonging to the family of the hematopoietins, liberated in response to infection, burns, trauma, and neoplastic diseases. It seems that an overproduction of IL-6 might play an important role in the pathophysiology of MG. Moreover, it has been discussed the possible role of IL-6 as a modulating factor either in proliferation or in differentiation of pleomorphic adenoma cell line into myoepithelioma. The authors present a rare case of parotid myoepithelioma occurred in a patient affected by myasthenia gravis and suppose a possible IL-6 mediated relationship between myasthenia gravis and parotid myoepithelioma.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Parotídeas
/
Interleucina-6
/
Mioepitelioma
/
Miastenia Gravis
Limite:
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
Med Hypotheses
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália