Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T.
J Magn Reson Imaging
; 24(5): 1140-7, 2006 Nov.
Article
em En
| MEDLINE
| ID: mdl-17024660
ABSTRACT
PURPOSE:
To test the repeatability of a reference region (RR) model for the analysis of dynamic contrast-enhanced MRI (DCE-MRI) in a mouse model of cancer at high field. MATERIALS ANDMETHODS:
Seven mice were injected with 10(6) 4T1 mammary carcinoma cells and imaged eight to 10 days later on a Varian 7.0T scanner. Two DCE-MRI studies were performed for each mouse (separated by 2.5 hours). The RR model was used to analyze the data, and returned estimates on the perfusion-permeability index (Ktrans) for the RR and the tissue of interest (TOI), as well as the extravascular extracellular volume fraction (ve) for the TOI.RESULTS:
When the first injection was compared with the second injection, all parameters tested were highly correlated (r2=0.90, 0.62, 0.82 for the RR Ktrans, TOI Ktrans, and TOI ve, respectively, with P<0.001 for all). To observe a statistically significant change (at the 5% level) in a treatment study with seven animals in each group, log10 changes of 0.084 and 0.077 in the tumor Ktrans and ve, respectively, are required.CONCLUSION:
If a reliable arterial input function (AIF) is unavailable, the RR model is a reasonable alternative to measuring MRI contrast-agent (CA) kinetics in mouse models of cancer at high field.
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Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Imageamento por Ressonância Magnética
/
Interpretação de Imagem Assistida por Computador
/
Aumento da Imagem
/
Neoplasias Mamárias Animais
/
Gadolínio DTPA
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Magn Reson Imaging
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos