[Effect of vasoactive intestinal peptide and epidermal growth factor on the adhesion of eosinophils to bronchial epithelial cells].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 31(5): 772-5, 781, 2006 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-17062950
OBJECTIVE: To investigate the effect of intrapulmonary regulatory peptides on adhesion of eosinophils (EOS) to bronchial epithelial cells (BECs). METHODS: Two regulatory peptides, namely vasoactive intestinal peptide (VIP) and epidermal growth factor (EGF) were investigated. VIP and EGF were observed on the secretion of ILs and expression of intercellular adhesion molecule-1 (ICAM-1). RESULTS: VIP and EGF could decrease ILs secretion and ICAM-1 expression. CONCLUSION: VIP and EGF inhibited the adhesion of EOS to BEC in the inflammatory process to lighten the airway inflammation.
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Base de dados:
MEDLINE
Assunto principal:
Brônquios
/
Peptídeo Intestinal Vasoativo
/
Eosinófilos
/
Fator de Crescimento Epidérmico
/
Células Epiteliais
Limite:
Animals
Idioma:
Zh
Revista:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Assunto da revista:
MEDICINA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
China