Norepinephrine and serotonin release upon impact injury to rat spinal cord.
J Neurotrauma
; 7(4): 219-27, 1990.
Article
em En
| MEDLINE
| ID: mdl-1707100
ABSTRACT
Microdialysis sampling was used to characterize the release of norepinephrine and serotonin upon impact injury to the rat spinal cord. Increases in extracellular norepinephrine concentrations in response to injury were small and of short duration. In contrast, serotonin concentrations quickly rose 35-90 times following injury and took 30-45 min to return to control levels. Bleeding caused by injury was probably the major source of the increased serotonin levels. Our results allow a role for serotonin in secondary damage upon injury to the spinal cord but suggest that norepinephrine is not a very significant contributor to such damage.
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Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Serotonina
/
Norepinefrina
Limite:
Animals
Idioma:
En
Revista:
J Neurotrauma
Assunto da revista:
NEUROLOGIA
/
TRAUMATOLOGIA
Ano de publicação:
1990
Tipo de documento:
Article