Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro.
Anticancer Res
; 26(5A): 3561-6, 2006.
Article
em En
| MEDLINE
| ID: mdl-17094483
ABSTRACT
BACKGROUND:
2-Deoxy-D-glucose (2-DG) is an analog of glucose that is preferentially captured by tumors and is accumulated in transformed cells, because the phosphorylated molecule (2-DG-6P) cannot be metabolized or diffused outside the cells. Targeted with a fluorine atom, 18F-DG is currently used to visualize malignant tumors (PET scan). Although cancer cells have been reported to be strongly dependent on glycolysis (Warburg effect), very few reports have studied the inhibitory effects of 2-DG on cancer. MATERIALS ANDMETHODS:
Our objective was to study, in a large panel of human malignant cells of various origins (ovarian, squamous, cerebral, hepatic, colonic and mesothelial), if the inhibitory activity of 2DG against tumor growth could be considered a general phenomenon and to determine its effect on the cell cycle.RESULTS:
Four types of response in the different cell lines were observed when cells were cultured in the presence of 2-DG (5 mM) continuous exposure proliferation slow down; proliferation arrest without signs of apoptosis; strong cell cycle arrest accompanied by moderate apoptosis induction; massive apoptosis.CONCLUSION:
2-DG appears as an interesting new therapeutic agent against cancer in vitro, and should be tested in in vivo studies.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Apoptose
/
Desoxiglucose
/
Proliferação de Células
/
Neoplasias
/
Antimetabólitos
Limite:
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
França