Diagnostic accuracy of cardiac markers for myocardial damage after radiofrequency catheter ablation.
J Interv Card Electrophysiol
; 16(3): 169-74, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-17103317
ABSTRACT
AIMS:
This study compares serum markers of myocardial damage incurred during radiofrequency catheter ablation (RFCA). METHODS ANDRESULTS:
Blood was sampled from 34 patients with atrial flutter (n = 16), atrioventricular nodal reentrant tachycardia (AVNRT; n = 13), and Wolff-Parkinson-White syndrome (WPW; n = 5) to measure creatine kinase MB subfraction (CK-MB), human heart-type fatty acid protein (h-FABP), and cardiac troponin T (cTnT) values at baseline and after RFCA. The controls comprised 12 patients without significant elevation of all myocardial markers during electrophysiological study (EPS) without RFCA. h-FABP values did not elevate significantly, whereas CK-MB and cTnT demonstrated significant change after RFCA (P < 0.001). Neither peak h-FABP nor CK-MB correlated with following RFCA parameters delivery duration, number of RFCA discharges, and cumulative RFCA energy. In contrast, correlations were significant between mean peak values of cTnT and these RFCA parameters (all P < 0.05). The sensitivity (71.6%) and specificity (35.6%) of h-FABP were inferior to those of cTnT (93.3% and 89.8%, respectively).CONCLUSION:
h-FABP is an insensitive and less specific marker of myocardial damage in RFCA much along the lines of CK-MB and when compared with the proven accuracy of cTnT.
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Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Biomarcadores
/
Ablação por Cateter
/
Troponina T
/
Creatina Quinase Forma MB
/
Proteínas de Ligação a Ácido Graxo
/
Miocárdio
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Interv Card Electrophysiol
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Japão