CD30 expression utilization for the accuracy of classical Hodgkin's lymphoma staging.
Rom J Morphol Embryol
; 47(2): 113-7, 2006.
Article
em En
| MEDLINE
| ID: mdl-17106517
ABSTRACT
INTRODUCTION:
The presence of Reed-Sternberg malignant cells is absolutely necessary for Hodgkin's lymphoma diagnostic, but it is not always sufficient because can be observed Reed-Sternberg-like cells in other malignant and benign diseases, too. The CD30 expression at Hodgkin and Reed-Sternberg level can give us supplementary information in differential diagnostic and can be used as progressive disease factor. MATERIAL ANDMETHODS:
Our study was composed from 63 cases histopathological diagnosed with Hodgkin's lymphoma and hospitalized in Hematology Department of County Hospital Timisoara. CD30 expression was immunohistochemical semi-quantitative evaluated using clone BerH2 as primary antibody and APAAP-New Fuchsin as visualization system. RESULTS AND DISCUSSIONS The increasing of CD30 expression occurs in the same time with advanced stages and the disease progression (p =0.001). For I and II stages CD30 expression does not overcome (-/+) category while the III and IV stages, all the cases are situated in (+/-) and (+) categories. No connection can be noticed between histological type and CD30 expression (p < or = 1). We consider that using this staining, although less used in Romania, must be done in all Hodgkin's lymphoma and Hodgkin's lymphoma-like cases. We say that because the main cause of relapses is represented by inadequate clinical staging and diagnostic.CONCLUSIONS:
In our study, the increasing of CD30 expression is associated with advanced disease stage. We recommend reinvestigating and restaging all cases that was included into an incipient stages and they have a CD30 expression situated in (+/-) and (+) intervals because some lymph nodes could be overlooked.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Doença de Hodgkin
/
Antígeno Ki-1
Limite:
Adolescent
/
Adult
/
Child
/
Humans
/
Middle aged
Idioma:
En
Revista:
Rom J Morphol Embryol
Assunto da revista:
ANATOMIA
/
EMBRIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article