A C-terminal aldehyde analog of the insect kinins inhibits diuresis in the housefly.
Peptides
; 28(1): 146-52, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17134792
ABSTRACT
The insect kinins are present in a wide variety of insects and function as potent diuretic peptides in flies. A C-terminal aldehyde insect kinin analog, Fmoc-RFFPWG-H (R-LK-CHO), demonstrates stimulation of Malpighian tubule fluid secretion in crickets, but shows inhibition of both in vitro and in vivo diuresis in the housefly. R-LK-CHO reduced the total amount of urine voided over 3 h from flies injected with 1 microL of distilled water by almost 50%. The analog not only inhibits stimulation of housefly fluid secretion by the native kinin Musdo-K, but also by thapsigargin, a SERCA inhibitor, and by ionomycin, a calcium ionophore. The activity of R-LK-CHO is selective, however, as related C-terminal aldehyde analogs do not demonstrate an inhibitory response on housefly fluid secretion. The selective inhibitory activity of R-LK-CHO on housefly tubules represents an important lead in the development of environmentally friendly insect management agents based on the insect kinins.
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Base de dados:
MEDLINE
Assunto principal:
Diurese
/
Moscas Domésticas
/
Cininas
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos