[Synthesis and antibacterial activities of 7-{4-[2-[2-substituted-4-((5S)-5-acetylaminomethyl-2-oxo-oxazolidin-3-yl)}-phenyl] -ethyl]-piperazin-1-yl}-fluoroquinolones].
Yao Xue Xue Bao
; 41(10): 990-9, 2006 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-17184119
ABSTRACT
AIM:
To find out new oxazolidinone-fluoroquinolone derivatives with high antibacterial activity.METHODS:
Some 7-{4-[2-[2-substituted-4-((5S)-5- acetylaminomethyl-2-oxo-oxazolidin-3-yl)-phenyl]-ethyl]-piperazin-1-yl}-fluoroquinolones were designed and synthesized, and their antibacterial activities were tested in vitro.RESULTS:
Twenty target compounds were obtained and their structures were confirmed by 1H NMR and MS. The target compounds had high antibacterial activities in vitro, especially, the activity of compound 22 against Enterococcus faecium was 16-fold and 64-fold more potent than that of linezolid and norfloxacin, respectively, and its MIC value against Staphylococcus aureus was 4-fold lower than that of linezolid.CONCLUSION:
The oxazolidinone-fluoroquinolone derivatives improved the antibacterial activities.
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Base de dados:
MEDLINE
Assunto principal:
Oxazolidinonas
/
Fluoroquinolonas
/
Antibacterianos
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
China