Anti-P. gingivalis response correlates with atherosclerosis.
J Dent Res
; 86(1): 35-40, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17189460
ABSTRACT
Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to examine the atherogenic effect of repeated immunizations with either or both of these agents, and to determine if molecular mimicry of bacterial heat-shock protein (HSP), termed GroEL, and host (h) HSP60 was involved. Atherogenesis was examined in apolipoprotein-E-deficient (-/-) mice following intraperitoneal immunizations with P. gingivalis, C. pneumoniae, P. gingivalis, and C. pneumoniae or vehicle. Lesion area in the proximal aorta and levels of serum antibodies to P. gingivalis, C. pneumoniae, and GroEL were measured. The increased pathogen burden of P. gingivalis, but not of C. pneumoniae, enhanced atherosclerosis. hHSP60 was detected in lesions, and in P. gingivalis-immunized mice, lesion development was correlated with anti-GroEL antibody levels, supporting the involvement of molecular mimicry between GroEL and hHSP60.
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Base de dados:
MEDLINE
Assunto principal:
Porphyromonas gingivalis
/
Aterosclerose
Limite:
Animals
Idioma:
En
Revista:
J Dent Res
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Austrália