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Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project.
Arthritis Rheum ; 56(1): 244-54, 2007 Jan.
Article em En | MEDLINE | ID: mdl-17195228
ABSTRACT

OBJECTIVE:

The high prevalence of systemic lupus erythematosus (SLE) among African American women may be due to environmental exposures, genetic factors, or a combination of factors. Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE.

METHODS:

Residential histories were obtained by interviewing 93 SLE patients from 3 predominantly African American neighborhoods in Boston. Residential addresses and locations of 416 hazardous waste sites in the study area were geocoded using ArcView software. Time-varying Cox models were used to study the effect of residential proximity to hazardous sites, GST genotype, and interaction between genotype and exposure in determining age at diagnosis.

RESULTS:

The prevalence of SLE among African American women in these neighborhoods was 3.56 SLE cases per 1,000. Homozygosity for GSTM1-null and GSTP1 Ile105Val in combination was associated with earlier SLE diagnosis (P = 0.03), but there was no association with proximity to 416 hazardous sites. Available data on specific site contaminants suggested that, at a subset of 67 sites, there was higher potential risk for exposure to volatile organic compounds (P < 0.05 with Bonferroni correction). GST genotypes had a significant interaction with proximity (P = 0.03) in analyses limited to these sites.

CONCLUSION:

There was no independent association between residential proximity to hazardous waste sites and the risk of earlier SLE diagnosis in this urban population. However, analysis of a limited number of sites indicated that the risk of earlier SLE associated with proximity to hazardous sites might be modulated by GST polymorphisms.
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Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Resíduos Perigosos / Predisposição Genética para Doença / Exposição Ambiental / Glutationa Transferase / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Arthritis Rheum Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Estados Unidos
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Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Resíduos Perigosos / Predisposição Genética para Doença / Exposição Ambiental / Glutationa Transferase / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Arthritis Rheum Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Estados Unidos