Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.
J Med Chem
; 50(5): 897-900, 2007 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-17269759
ABSTRACT
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Pirrolidinas
/
RNA Polimerase Dependente de RNA
/
Hepacivirus
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido